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Despite the incredible advancements in wound care and regenerative medicine, key agenciesincluding the Centers for Medicare & Medicaid Services (CMS), the Food and Drug Administration (FDA), and the Agency for Healthcare Research and Quality (AHRQ)still lack a unified, standardized definition of what constitutes a "skin substitute." They actually rely on a list of surgical procedures to define products, The CPT manual, which explicitly states it does define products

The extract of AM has been shown to reduce viral load in patients with HBV, partly due to its ability to stimulate endogenous interferon production and enhance the immune system, in addition to its antioxidant and detoxifying effects [40]