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doi: 10.1007/s40265-019-01134-9

10.1006/enrs.2000.4068 40 DionL

Globally, sepsis is responsible for an estimated 11 million deaths every year, making it a leading cause of mortality worldwide

One month after ALP cessation, decreases in ERK1/2-related signaling were observed within this pathway, molecular effects resembling those observed during periods of abstinence from opioids, suggesting that ALP exposure poses long-lasting detrimental effects that may facilitate drug intake later in life