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10.1097/ACI.0000000000000100 49 GuoH.LiuM

Furthermore, studies in a murine model demonstrated that EVs transported by blood can reduce mHTT levels and neuronal degeneration

doi: 10.1016/j.cbi.2010.07.004

Because of this caveat, it cannot be said conclusively that PDI is more sensitive to oxidative damage or degradation, however, it is a plausible mechanism