glutathione peroxidase thioredoxin reductases

glutathione peroxidase thioredoxin reductases and Systems Team:UNSW Australia/Model/Glutathione System

Name: glutathione peroxidase thioredoxin reductases and Systems Team:UNSW Australia/Model/Glutathione System
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Team:UNSW Australia Model Glutathione System Abbreviations: glutathione, GSH; glutathione peroxidase, GPx; Download Scientific Diagram Three dimensional structure of a mammalian thioredoxin reductase: Implications for mechanism and evolution of a selenocysteine dependent enzyme PNAS Photo oxidation induced inactivation of the selenium containing protective enzymes thioredoxin reductase and glutathione peroxidase ScienceDirect

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Moreover, ALA exerts antioxidant effects via a dual mechanism: (i) rapid redox-cycling between its disulfide (ALA) and dihydrolipoate (DHLA) forms, which directly quenches ROS without transcriptional activation, and (ii) secondary upregulation of the Nrf2 pathway and suppression of NF-B nuclear translocation (Ghibu et al., 2009)