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Autophagy: a double-edged sword in intervertebral disk degeneration

Kumar T, Kumar P, Saini N, Bhalothia SK, Prakash C, Mahla AS, et al

Interestingly, gene inhibition and CB-839, an inhibitor of GLS activity, can eliminate SREBP activation, suggesting that ammonia derived from GLS is a critical mediator of lipogenesis (90, 142)