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Determination of conductivity The ionic conductivity of each sample was measured at 25 C by using a conductivity electrode (LE703, Mettler Toledo, USA) connected to a conductivity metre (FiveGo Cond meter F3, Mettler Toledo, USA) over a range of 0.01200 mS/cm

The study was carried out in accordance with the Declaration of Helsinki, and the clinical trial protocol was approved by the Ethics Committee of every participating center

Consequently, disruption of mitochondrial transport to the synapse is a primary driver of synaptic degeneration and eventual neuronal death ( Evidence from cellular and murine models indicates that Tau overexpression and hyperphosphorylation severely disrupt the localization and distribution of mitochondria ( Similarly, iPSC-derived neurons with the N279K and P301L Tau mutations show a significant reduction in anterograde axonal transport compared to healthy controls ( 5.3 ROS-driven amplification loops Mitochondrial dysfunction is an early-stage hallmark of AD, characterized by diminished ATP synthesis and a reciprocal surge in reactive oxygen species (ROS) (89)