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These differences are likely to reflect monovalent binding of Fab compared with divalent binding of whole IgG, depending upon the spacing of targeted epitopes on the virion surface 94,95,96

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When mitochondrial damage accumulates above a certain threshold, for example in response to energy deprivation, OS, or hypoxia, cells activate a mechanism to selectively target and remove damaged mitochondria via the autophagic machinery to renew the mitochondrial pool (231)

298,299,300 However, the addition of citrulline, a precursor for arginine synthesis, can promote the expression of this molecule by prolonging the half-life of CD3