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31 HSA-SNO binds GSH molecules, releasing nitric oxide (NO), which additionally occupies oxygen binding sites within the mitochondria, thus reducing cellular respiration of cancer cells and indirectly increasing the oxygen concentration needed for PDT

For instance, elevated CHAC1 mRNA levels are associated with increased recurrence risk in these cancers, underscoring its clinical relevance ( Pan-cancer analyses reveal that CHAC1 expression is highly variable, being upregulated in many cancers (e.g., breast, ovarian, lung, bladder carcinomas) and downregulated in others (e.g., certain head/neck, kidney, and brain cancers) (Li, D

Introduction Cell death is a fundamental biological process that governs cell fate, tissue regeneration and host immune responses (1)

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