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Dysfunction in either the urea or glutamine synthetase cycle triggers disorders such as hyperammonemia and hepatic encephalopathy (Qvartskhava et al., 2015

& McCluskey, J

Ethics declarations Competing interests During the past 3 years, the author has been a consultant for Bristol Myers Squibb, GSK, Mozart Therapeutics, Ono Pharmaceutical, Precigen ActoBio, Sanofi, SQZ Biotech, Takeda and Topas Therapeutics