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In a 6-month, randomized, double-masked, placebo-controlled study, ruboxistaurin enhanced skin microvascular blood flow at the distal calf, reduced sensory symptoms, improved the quality of life, and was well tolerated in DPN patients

[DOI] [PubMed] [Google Scholar] 238.Ahmadian M, Duncan RE, Varady KA, Frasson D, Hellerstein MK, Birkenfeld AL, et al

The findings indicate that the effects of the medications needed to be monitored closely, the researchers said, stressing that changes could be made to help fight and potentially prevent these effects

Others may need a more gradual nutrition plan, exercise support, behavioral coaching, or evaluation for newer prescription options