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Using protein degraders, such as chaperone-mediated protein degraders (CHAMPs), to simultaneously degrade KRAS and associated receptors like HSP90 has been also reported to reduce cell survival despite KRAS mutation-driven oncogenicity [168]

however, this is FDA staff's proposed position going into the meeting, not a final action, and the committee's discussion, any vote, and FDA's ultimate decision are still pending, so the outcome of the review is not yet known

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