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The pathological effects of oxidative stress on spermatozoa can be grouped into three main categories: lipid peroxidation, DNA fragmentation, and protein oxidation

Additionally, erythrocytes generate ROS due to hemoglobin autooxidation, Fenton reaction, NADPH oxidase- and xanthine oxidoreductase-mediated reactions, and scavenge exogenous immune cells-derived ROS [17]

The authors concluded that "those with ASDs are affected by an imbalance between their anti-oxidative and oxidative stress systems, a condition which could be treated with glutathione supplementation"

490 Furthermore, Sir2 , as a mammalian homolog of SIRT1, is the downstream effector of increased Nmnat activity, which can lead to axon protection in Wallerian degeneration slow mice