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In a RCT comparing low- to intermediate-risk PCa patients treated with either surgery or RT (without ADT), the sexual function scores of the Expanded Prostate Index Composite (EPIC-26) were significantly higher for men receiving RT at two years post-treatment [306]

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Breast cancer cells were able to survive the harsh conditions of hypoxia by upregulating a glycolytic enzyme, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 (PFKFB4), compared to the normoxic controls in vitro and in vivo ( 4 Therapy-induced rewiring of mitochondrial metabolism: evidence for plasticity Plasticity is defined by a cells ability to adapt its phenotypes in response to the environment in a reversible manner through non-permanent molecular mechanisms, usually entailing epigenetic, transcriptional, post-transcriptional, translational, and/or metabolic rewiring