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Meanwhile, insulin resistance is also associated with defects in the insulin-induced stimulation of glycogen synthesis, for example, T2DM patients have lower fasting and postprandial hepatic glycogen content [38]

For example, systemic inhibition of glycolysis can impair normal tissues with high glucose dependence, such as brain and heart, exacerbating chemotherapy-induced toxicity, especially cardiotoxicity from anthracyclines

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