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Vicious cycle of iron dyshomeostasis and A/tau An abnormal increase in iron levels in the AD brain is a well-documented phenomenon, especially in the regions most severely affected by neurodegeneration (6)

However, problems begin to occur when the number of free radicals exceeds what our bodies can process naturally, resulting in an increased presence of free radicals that can damage cells and compromise bodily functions

The availability of PHGDH inhibitors presents an exciting opportunity for preclinical and clinical trials targeting patients with PHGDH-amplified tumors [38]

[DOI] [PubMed] [Google Scholar] 32.Kumar C., Igbaria A., DAutreaux B., Planson A.G., Junot C., Godat E., Bachhawat A.K., Delaunay-Moisan A., Toledano M.B