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The search was performed in multiple databases, including PubMed, Web of Science, and Embase, and was supplemented by manual searches using Google Scholar to ensure completeness

R.KaruppagounderS

Collectively, mitochondria as the primary generators and the recipients of oxidative damage, implies a vicious cycle wherein impaired mitochondria produce increased amounts of ROS, in turn leading to a progressive accumulation of damage that culminates in the process of aging (Figure 1)