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COX-2 induces and regulates inflammation by promoting the synthesis of different prostaglandins (PGs), which exhibit a variety of biological activities and participate in pathophysiological processes in the body in a variety of ways

When pitting edema is present, venous insufficiency should be investigated in women with lipedema by a venous duplex ultrasound of the legs

Botox creates more rigid commitment requiring quarterly treatments for maintenance with complete wrinkle return if stopping, though self-limiting nature means discontinuation remains option without permanent consequences beyond returning to pre-treatment baseline