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But those trials were small (approximately 300 subjects total across phases), short (up to 24 weeks), and used a route of administration that likely delivered minimal systemic exposure

Conversely, recent evidence has shown that proton beam therapy might reduce long-term neurocognitive and endocrine sequelae and improve functional outcomes and quality of life in patients with CO CP [20, 21] by offering superior dose conformity that spares surrounding healthy brain tissue, particularly the hypothalamus and pituitary gland, while also achieving tumour control rates comparable to photon therapy while potentially improving functional outcomes and quality of life [22]

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