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23 [catalytic] , cdc 2 7.P11 [non-catalytic], cdc1.P13 [non-catalytic]) impaired cell viability, mutations in the catalytic subunits of Pol epsilon ( cdc20.M10 ) or Pol alpha ( swi7.H4 ) did not (Fig

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If we gave the starving slime mold extra glutathione, we were able to block this increase in ROS and, importantly, stop the formation of the multicellular aggregate, keeping the cells in a single-celled state. Starving Dicty alter their metabolism In turn, when they blocked glutathione production using an inhibitor, they found that instead of promoting an even faster aggregation, this reversed it, maintaining the single-celled state for longer