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Description

Toussirot, E., Bereau, M., Vauchy, C

Ferroptosis is a nonapoptotic form of regulated cell death, characterized by excessive iron-dependent accumulation of lipid peroxidation products [21]

(1) ROS directly attacks the mitochondria of chondrocytes, causing leakage of the electron transport chain (ETC) and further generating superoxide anion (O ), which forms a vicious cycle, inducing collapse of mitochondrial membrane potential and ATP synthesis disorder

The results of this model reveal high BACs in mice, along with significant elevations in serum ALT and AST levels, both peaking at 9 h after administration