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"Meta-analysis of ALCAR vs placebo in MCI and mild Alzheimer's." Int Clin Psychopharmacol 2003;18:61-71

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The supplementation for four weeks did not improve fat burning

Glycemic characteristics and insulin sensitivity are influenced by variations in the TCF7L2 and MTNR1b genes, which have been linked to different reactions to dietary fat and carbohydrate intake, respectively (167)