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Methods in Molecular Medicine, 62 , 7387

For instance, Opc is possessed only by the meningococcus, and Opa proteins have different affinities for CEACAM members, with meningococcal Opa primarily targeting CEACAM1 and gonococcal Opa proteins binding to CEACAM1, CEACAM5, CEACAM6, and CEACAM3 on epithelia, neutrophils, and lymphocytes (Sadarangani et al., 2011