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Human pluripotent stem cell-derived intestinal organoids for pharmacokinetic studies

Patients with known or suspected mitochondrial disease: Valproate induced acute liver failure and liver-related deaths have been reported in patients with hereditary neurometabolic syndromes caused by mutations in the gene for mitochondrial DNA polymerase (POLG) (e.g., Alpers-Huttenlocher Syndrome) at a higher rate than those without these syndromes (see Contraindications)

Freie Radikale reagieren mit normalen Zellstrukturen, wodurch die Zellen geschdigt werden und der Zelltod hervorgerufen werden kann

PubMed Chang CH, Tsai WC, Lin MS, et al