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Lakhal-Littleton S, Crosby A, Frise MC, Mohammad G, Carr CA, Loick PAM, et al

Therefore, targeting SRMS with PLX4720 holds the promise to improve the efficacy of platinum-based chemotherapy and overcome chemoresistance in ovarian cancer

The goal of reversible glutathionylation in this case is to modulate the availability of H 2 O 2 for second messaging while protecting mammalian cells from oxidative distress (Figure 3A)