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Dosage and Administration: For Cattle, Horses, Swine, and Sheep: Cattle and Horses: 10 - 25 mL Calves and Foals: 5 - 12 mL Swine: 2.5 - 10 mL per animal Piglets, Lambs, and Kids: 1 - 2.5 mL For Dogs and Cats: Dogs: 0.5 - 5 mL Cats: 0.5 - 2.5 mL Precautions: 1.Use caution when administering to pregnant or lactating animals

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Johns Wort can accelerate clearance and diminish efficacy, whereas inhibitors like ketoconazole, clarithromycin, certain protease inhibitors, or excessive grapefruit intake may elevate serum estradiol and increase adverse-event risk