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A proposed tolerated upper safety limit based on human clinical trials is up to three grams a day, but the longest trial at that dose was only up to four months

Safety and efficacy of Edaravone Dexborneol versus edaravone for patients with acute ischaemic stroke: a phase II, multicentre, randomised, double-blind, multiple-dose, active-controlled clinical trial

Because multiple mechanisms may contribute to resistance to every anticancer drug, it is not surprising that initial or acquired drug resistance is observed after treatment of most cell populations

They are present in 1% of newborns and increase in incidence throughout infancy and childhood