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Preliminary double-blind, placebo-controlled studies demonstrated the efficacy of melanotan in inducing penile erection in men with erectile dysfunction, although in a very restricted population.Unfortunately, there are no experimental data on the mode of action of melanotan II, as melanotan II is the first -MSH agonist inducing penile erection when injected peripherally

It targets three receptors (GLP-1, GIP, and glucagon) and is still in Eli Lilly clinical trials

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Co-administration with sildenafil enhanced erectile activity compared to sildenafil alone, offering a potential alternative for patients with inadequate single-therapy responses (6)