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CBD was able to prevent the increase of microRNAs associated with depression in the ventromedial prefrontal cortex in an unpredictable chronic stress induction model, with antidepressant-like effects mediated by the 5HT1A receptor ( In a study involving exposure to a high-fat diet and chronic stress, the effects of CBD on behavior and on the expression of neuroinflammatory genes in the ventromedial prefrontal cortex and hippocampus were demonstrated (Sabbag et al., 2025)

Together, these data demonstrated that the hypoxia/anaerobic glycolysis axis mediates CD8 + T M cellular dysfunction and exhaustion at transcriptomic level in COVID-19

Data availibility All data generated or analyzed during this study are included in this published article

Given the low oral bioavailability of L-Carnitine it's important to note that the upper range of dosing should be considered in order to mimic the effects of an intramuscular injection