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To investigate the association between the population structure of our dataset and key metadata factors, such as health status (diseased or healthy), genome type (MAGs or isolates) and country of origin of the samples), we performed a permutational multivariate analysis of variance (PERMANOVA) test using the adonis2 function from the vegan R package 49

of Orthopedics and Traumatology, "251" Hellenic Air Force General Hospital, 4 Laboratory for Research of the Musculoskeletal System, School of Medicine, National and Kapodistrian Univ