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Selective serotonin reuptake inhibitors (SSRIs) are first-line antidepressants commonly used in clinical practice, however, they can have poor tolerability, delayed onset of therapeutic effects and limited efficacy in patients with milder depression [3]

We now know that they are highly expressed in the nervous system and are regulating the ability to learn and other higher-level cognitive tasks. Orai1 channels, named after the Horae who guarded the gates to Mount Olympus in Greek mythology, are calcium-selective ion channels