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A systematic review found favourable evidence for the use of NAC in several psychiatric and neurological disorders, particularly autism, Alzheimer's disease, bipolar disorder, depression, obsessive-compulsive disorder, schizophrenia, drug-induced neuropathy and progressive myoclonic epilepsy

Then the researchers know that if one group does better than the other, its because of the different treatment

Moreover, high doses of L-Arg can induce the expression of arginases, which metabolizes L-Arg, and increase arginase activity is associated with eNOS uncoupling and endothelial dysfunction [122, 226, 227]