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Gastroenterology (2004) 127(3):87082

In both IBD patients and animal models, an increase in the number of M1 macrophages and a significant elevation in serum levels of pro-inflammatory cytokines, including TNF-, IL-1, and IL-6, have been observed, with ROS playing a pivotal role as a signaling molecule in triggering and amplifying the inflammatory response

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Meanwhile, the activity of nicotinamide adenine dinucleotide (NAD + )-dependent deacetylases Sirtuins [especially sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3)] decreases due to NAD + depletion, leading to hyperacetylation of multiple target proteins, which tends to enhance NF-B signaling and inhibit fatty acid oxidation (52, 53)