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Adenocarcinoma of the bile ducts appears in 8% to 15% of patients with PSC, rendering it a premalignant condition (Chalasani et al, 2000

In contrast, the bulkier Y37 rAmy in rAmy-bound AMY 2 R prevents equivalent interactions of N35 rAmy with RAMP2, and instead the bulkier Y37 rAmy forms interactions with E101 RAMP2 and F111 RAMP2 stabilising the peptide at the CTR/RAMP ECD interface in the bypass conformation

Occasionally, our Miami peptide therapy patients may experience some mild side effects, though peptide therapy offers a much lower risk of unwanted symptoms than alternative treatment methods