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There is no use of gluten, artificial colors, or any other harsh chemicals

NRF2 also controls the expression of glutathione S-transferases (GST) and glutathione peroxidases 2 (GPX2), which are enzymes known for detoxifying epoxide and H 2 O 2 , respectively

Some encephalopathy Systemic Short stature Cardiomyopathy: 3 patients Renal tubulopathy: 1 patient Course Progressive May be worse with pregnancy Severe forms Encephalopathy: Lethargy Death in early childhood Milder patients: Survive to 3rd decade Laboratory Anemia, Sideroblastic Serum lactate: High Other metabolic: Ketosis

Native MS of the ligand-bound SOD1 showed the typical native MS profile of SOD1 where monomer arises as +7 and +8 multiply charged ions, and the dimer as +9 to +12 ions with the major component of dimer signal being 10+ and 11+ charged ions (Supplementary Figure 4)