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Given that GPR146 is most highly expressed in mature adipocytes, obesity-associated changes such as increased immune infiltration and stromal remodeling may reduce the relative abundance of GPR146-expressing cells in bulk tissue profiles

[8] As might be expected of an enzyme involved in regulating NO levels and signaling, pleiotropic effects are observed in GSNOR knockout models

DOI: 10.1016/j.molmet.2018.02.006

A significant study involving rats exposed to ACR at a dosage of 50 mg/kg for 11 days revealed notable increases in critical oxidative stress markers, including malondialdehyde (MDA) and nitric oxide