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MELATONIN RELEASE Postsynaptic receptors located in the innervating pituitary, superior cervical ganglion regulate melatonin release

At low doses commonly used, nephrotoxic effects are not common, which are usually represented by tubulointerstitial disease of the kidney and rhabdomyolysis[47]

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used in long-term human clinical trials Intravenous injection Used primarily for pharmacokinetic characterization and acute dosing studies in humans Intraperitoneal injection Standard route for chronic rodent studies