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This suggests that the downregulation of EPAS1 not only correlates with lower hemoglobin concentrations in Tibetans but also contributes to reduced inflammation and enhanced energy metabolism through improved HIF-1-BNIP3/NIX-mediated mitophagy, highlighting the effectiveness of natural selection

This can lead to a person overreacting, taking risks, feeling depressed or anxious and this may also be what then contributes to the physiological occurrence of IBS in many people with ADHD