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If the desired results are not seen after 3-6 months, or if the patient cannot tolerate the medication, discontinuation or alternative treatments may be considered

Campagna R, Salvolini E, Pompei V, Pozzi V, Salvucci A, Molinelli E, Brisigotti V, Sartini D, Campanati A, Offidani A (2021b) Nicotinamide N-methyltransferase gene silencing enhances chemosensitivity of melanoma cell lines