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Ergothioneine concentrates in parts of your body where there are lots of free radicalsthe lens of your eye and your liver, for example, as well as sensitive tissues such as bone marrow and semen

this reduces depletion of muscle glycogen

Reactive intermediates are either produced by reactions involving enzymes such as nicotinamide adenine dinucleotide phosphate (NADP)H [6], nitric oxide synthase, or by nonenzymatic reactions through mitochondrial electron transport chain [46], and reduced transition metals [47]

Furthermore, ANT induces an increase in oxidative stress by inhibiting important antioxidant enzymes such as GSH, CAT, and SOD [35, 36]