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It is necessary to establish multi-center, cross-platform data integration systems to strengthen the connection between basic research and clinical data, improving drug prediction accuracy and therapeutic consistency [188]

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This three layer device, consisting of a fibrin hydrogel cell layer, a mechanical actuation layer, and a glass cover, recapitulated joint dynamics and showed that SYN321 downregulated inflammatory markers, reduced matrix metalloproteinase activity, limited extracellular matrix degradation, and preserved microtissue architecture (Palma et al., 2024)