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Acknowledgements This work was financially supported by the National Natural Science Foundation of China (81870423 and 82073914), the Major Project of the Natural Science Research of Jiangsu Higher Education Institutions (19KJA310005), the Open Project of Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica (JKLPSE202005, JKLPSE201815, and JKLPSE 201804), the Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), and the Postgraduate Research & Practice Innovation Program of Jiangsu Province (SJCX20_0536 and KYCX20_1493)

Women Experiencing: Aging skin Bone density loss Nervousness / anxiety Emotional reactivity and sensitivity Frequent night urination Hair thinning Hot flashes / night sweats / day sweats Fatigue Insomnia Weight gain unresponsive to diet and exercise Loss of libido Nervousness / anxiety Depression Dry / painful intercourse Men Experiencing: Loss of motivation / lack of vitality Loss of assertiveness / increased need for sleep Reduced physical stamina Weight gain unresponsive to diet and exercise Loss of muscle mass / inability to lose weight Breast development Joint pain Hair loss Declining mental ability Loss of libido Decreased ability to perform sexually Loss of morning erections

Chen D, Menon H, Verma V, Seyedin SN, Ajani JA, Hofstetter WL, Nguyen QN, Chang JY, Gomez DR, Amini A, Swisher SG , Blum MA, Younes AI, Barsoumian HB, Erasmus JJ, Lee JH, Bhutani MS, Hess KR, Minsky BD, Welsh JW