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Rev Environ Contam Toxicol, 112: 1-47

For example, melatonin, -endorphin, and phenylpropanolamine all lower seizure thresholds within a day

For mTYR, the narrow dual copper-binding site makes it more difficult for arbutin, which has two rings, to fit, especially in the MD-stable conformation of Arbutin_b, where the number of hydrogen bonds between arbutin and the pocket is much lower than in other conformations (Table 2)