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GCL activity and the expression levels of ferroptosis markers, GPX4 and acyl-CoA synthetase long-chain family member 4 (ACSL4), were remarkably improved in the REST -knockdown cells under the HR condition, rather than other ferroptosis-associated proteins (GCLC, dihydrofolate reductase [DHFR], and ferroptosis suppressor protein 1 [FSP1]), apoptosis-associated proteins (B cell leukemia/lymphoma 2 [Bcl-2] and Bcl-2associated X [Bax]), autophagy-associated proteins (microtubule-associated protein 1A/1B-light chain 3 [LC3] and sequestosome 1 [p62]), or pyroptosis-associated proteins (caspase-1 and GSDMD) (Figure 4D and Supplemental Figure 11, C and D)

Nutrition 2013;29:886-91.ArticlePubMed 36

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