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Such a CoQ-free pool can be applied by enzymes linking the MRC to other pathways, like the fatty acid -oxidation and amino acid catabolism, pyrimidine de novo biosynthesis, proline, arginine, and glyoxylate metabolism, glycine metabolism, and sulfide oxidation metabolism that some of them are attached to metabolic pathways in other compartments (Pradhan et al., 2021)

4B) is consistent with a scenario in which the elevated ROS levels by c-SRC activation are squelched by augmented PPP under glucose deprivation and with a lactic acid signaling

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NAD can help energy and recovery in some patients, but it is not universally transformative