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Conclusion While vitamin B12 injections are effective and generally safe, rare but serious adverse effects such as hypersensitivity and anaphylactic reactions can occur, particularly with parenteral administration

Patients of both sexes, aged 18 years, with BMI 1830 kg/m 2 , radiologically confirmed BMLs accompanied by significant knee pain or activity limitation, neutral or varus limb alignment without gross deformity, intact cruciate ligaments and menisci, and no intra-articular injections within the preceding 12 months were eligible

Most people experience no systemic effects at standard research doses

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