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People with higher levels of oxidative stress or lower baseline glutathione may notice more dramatic benefits from supplementation compared to those with already-optimal levels

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This is often because physicians are trying to limit side effects

In conclusion our studies indicate that oral L-GSH supplementation in individuals with T2DM for three months was able to maintain the levels of GSH, reduce oxidative stress, and diminish mycobacterial burden within in vitro generated granulomas of diabetics