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Mast cells located in the submucosa of the respiratory tract are known to be activated by the SARS-CoV-2 virus (1) (see Figure 1 )

For example, it was shown that changes in the microbial composition correlated with an increase in intestinal permeability in alcohol-dependent subjects (Leclercq et al., 2014)

doi: 10.3389/fpsyt.2021.751575 162 ShakerEEl AgamiOSalamahA

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