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During stroke, however, elevated extracellular glutamate causes excitotoxicity, blocking system Xc function and reducing GSH synthesis, thereby triggering ferroptosis (147)

The illness is the second most common reason for death throughout the world, and per official projections, it is predicted that there will be approximately 26 million new cancer cases and 17 million cancer-related deaths annually by 2030 (2,5)

The solvent was evaporated under reduced pressure and the crude product was purified by flash chromatography (hexane: acetone 85:157:3) to give 152 mg of the unseparable mixture of 20 and 21 with approximately 1.4:1 ratio, as a yellow foam

doi: 10.1038/nature11218