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This is a recurring theme in research-chemical quality: the label is not the molecule, and conclusions drawn from an uncharacterized preparation carry a large asterisk regardless of how careful the downstream experiment is

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Across the research pipeline, the field remains diagnosis-centric, then monitoring and prognostication, and only lastly treatment, reflecting an early emphasis on identifying high-sensitivity and high-specificity markers to enable timely antifungal therapy

First, most preclinical studies have not specifically tested metastatic CC or with lymphatic metastasis as an end-point