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Am J Hypertens 23(12):13181325 Dauchet L et al (2006) Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies

Notably, most clinical investigations studied women (1404 female versus 83 male participants), which is expected since estrogen declines after age 30 years, and further estrogen decline with aging represents health challenges, as well as a reduction in QOL [9, 10, 19,20,21,22] and a degradation in the most visible organ of the bodythe skin [9, 10]

doi:10.1039/B819842J Rabenstein DL (1973) Nuclear magnetic resonance studies of the acid-base chemistry of amino acids and peptides

451 Fisetin, another natural senolytic drug, has also been studied in the clinical stage (Table 3) for the treatment of age-related diseases, and its use is expected to lead to breakthroughs in the clinical research of senolytics